Sorting the wheat from the chaff in dopamine neuron-based cell therapies.
نویسنده
چکیده
The field of neuronal transplantation for Parkinson’s disease has evolved through a remarkable convergence of ideas and techniques (1, 2). Over the last decade, attempts to replace missing dopamine neurons have evolved from an innovative and complex fetal dopamine cell transplantation method toward a potential scalable method that depends on stem cell-derived dopamine neurons (2–10). For functional recovery to occur, the precise midbrain dopamine neuron (denoted A9) lost—which normally connects exactly with the caudate putamen target and inititates movement—needs to be replaced. A series of transplantation experiments using transgenic mice and elimination of the A9 neuron have documented the need for such specificity (1, 11). Therefore, in future transplantation trials, it will be essential to transfer the active and necessary midbrain dopamine neurons back to the patients.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 112 15 شماره
صفحات -
تاریخ انتشار 2015